A sow that fails to conceive after repeated matings: is it the sow's problem or some other cause?

(2) No eggs available for release
1. No follicle development: Sows are born with oocytes, and "no eggs available for release" means that various factors prevent follicles from developing into mature follicles.
Commonly seen in: ovarian hypoplasia, reckless use of estrus-inducing drugs, and malnutrition.
2. Ovarian hypoplasia (also called Turner syndrome): first described by Turner in 1938, accounting for 6.5% of cases of failure to conceive after repeated matings; it is caused by nondisjunction of the sex chromosomes in the boar's spermatocytes. It is a hereditary disease in which the gonads of the affected animal fail to develop and the ovaries are replaced by cord-like fibrous tissue; cull the animal.
3. Reckless use of estrus-inducing drugs: Each reproductive hormone has a specific use and time point for use. Some farmers, whether dealing with replacement gilts or multiparous sows, do not consider various triggering factors and simply feed "estrus-inducing powder" whenever the animal does not come into estrus. However, estrus-inducing powders on the market are highly varied, and once a poor-quality "estrus-inducing powder" containing only hormonal drugs such as diethylstilbestrol is purchased, it will cause sows to show estrus but not ovulate.
4. Impact of nutritional factors: Feed energy or protein being too high or too low can cause sows to become too fat or too thin.
Too fat: fat infiltration within the ovaries, fatty degeneration of follicular cells, and follicular atrophy.
Too thin: lack of protein in the feed means the sow cannot provide the raw materials necessary for follicle growth.
Deficiency of vitamins and mineral elements: can cause ovarian degeneration or atrophy and thus no ovulation.
Mycotoxins: for example, zearalenone causes false estrus and also affects placental development.
A sow that fails to conceive after repeated matings: is it the sow's problem or? Do you know?