Introduction to Tylosin (Tylan), a Commonly Used Macrolide Antibiotic in Duck Clinical Practice

Source and properties: This product is extracted from the culture broth of Streptomyces fradiae. It is a white crystalline substance, weakly alkaline, and slightly soluble in water. Its salts are readily soluble in water. Tylosin tartrate, tylosin hydrochloride, and tylosin phosphate are commonly used in clinical practice.

Actions and uses: This product is an antibiotic specifically for livestock and poultry, with antibacterial activity against Gram-positive bacteria and some Gram-negative bacteria, such as Staphylococcus aureus, Streptococcus pyogenes, Mycoplasma, and Spirochetes, all of which it inhibits, and it is especially effective against Mycoplasma. However, its effect against Gram-positive bacteria is inferior to that of erythromycin.

Dosage and administration: Tylosin tablets, specification 0.2 g; tylosin tartrate water-soluble powder, specifications 2 g and 100 g; the oral dose for adult ducks is 25 mg per kg body weight, once daily, with a drinking water concentration of 500-800 mg/L, and a mixed feed concentration of 20-50 mg/kg. Precautions: The aqueous solution of this product readily forms complexes with ions such as iron, copper, and aluminum, resulting in loss of efficacy.