What polypeptide antibiotic drugs are commonly used in geese

Colistin

Source and properties: This product is extracted from the culture fluid of Bacillus polymyxa. It has five components, A, B, C, D, and E, belongs to the polypeptide compounds, and has similar basic chemical structures. In clinical application, colistin B and E are mainly used. Its sulfate is a white or light yellow powder, easily soluble in water.

Action and uses: This product has a strong antibacterial effect on Gram-negative bacteria, inhibiting bacteria at low concentrations and killing bacteria at high concentrations. It is mainly highly effective against Escherichia coli, Salmonella, Shigella, Pseudomonas aeruginosa, Pasteurella, and others, and is especially effective against Pseudomonas aeruginosa. However, it has no effect on Gram-positive bacteria or fungi. Clinically, it is mainly used to treat various infectious diseases caused by Pseudomonas aeruginosa and other Gram-negative bacteria.

Dosage and usage: Colistin sulfate E (colistin sulfate, colistin sulfate) tablets, specifications are 125,000 units, 250,000 units, (65,000 units is equivalent to 10 mg), expiration period 3 years. The oral dose for poultry is 30,000-80,000 units per kg body weight each time, 1-2 times a day.

Precautions: This product has obvious toxicity to the kidneys and nervous system. When used, the dosage should not be too large, and the course of treatment should not be too long; it also cannot be used together with aminoglycoside antibiotics such as gentamicin and streptomycin, otherwise its toxicity will be enhanced. This product is not absorbed when taken orally, so it cannot be used for the treatment of systemic infectious diseases.