How to effectively solve the mycotoxin problem? Brazil takes strong action and becomes a model country
Brazil: has taken strong action on the mycotoxin problem, a model country that effectively solves the mycotoxin problem
This post was last edited by Cui Ruowei on 2009-11-27 17:16
A model country that effectively solves the mycotoxin problem
Brazil: has taken strong action on the mycotoxin problem
Brazil has set another example with its world-leading position. Twenty-five years ago they decided to stop relying only on oil, and then began producing ethanol from sugarcane, which is about 5 times more efficient than extracting it from corn, and it does not affect global feed or food prices. This time its leadership is shown in the mycotoxin issue.
Brazil is one of the world's largest grain producers and exporters of poultry meat and pork. For many years grain growers were very fortunate, because their only mycotoxin problem was aflatoxin. Over the past 4 years, this situation has changed dramatically. Fusarium moniliforme toxin, F2 toxin and deoxynivalenol began to be detected in corn, wheat and soybeans, and at very high levels, affecting animal production.
Mycotoxin adsorbents that claim to provide solutions to all problems appeared, and their greater purpose was to sell products rather than truly solve the problem. Faced with the mycotoxin problem and so many products, the Brazilian government decided to take tough measures to provide a true solution to this major problem.
Unlike the United States, where carcinogenic substances are not allowed to be added to feed, or the European Union, which has regulations stipulating very low doses of mycotoxins in feed, Brazilians solved this problem in a very effective and feasible way. They realized they had a mycotoxin problem, so they established a committee composed of scientists and experts in the mycotoxin field to create and develop methods and regulations for approving mycotoxin additives (adsorbents, detoxifiers).
The committee concluded that a program should be implemented, approving mycotoxin adsorbents through three stages of testing, conducted at Brazilian universities considered to be in a leading position in the mycotoxin field. The Federal University and the LAMIC laboratory were appointed to carry out this program.
The LAMIC laboratory was founded 15 years ago and is currently one of the world's top five leading independent mycotoxin laboratories. This laboratory has 9 sets of HPLC equipment and one MS/MS spectrophotometer dedicated solely to independent mycotoxin analysis. At the same time, they also have their own pig and poultry research center for in vivo animal experiments. LAMIC is a financially self-sufficient laboratory, and its main function is to provide services to farmers, not to mycotoxin adsorbent manufacturers.
In vitro experiments
The approval procedure begins with in vitro experiments, carried out with different levels of mycotoxin adsorbents at different pH values, with mycotoxin levels varying between 1,000 ppb and 2,500 ppb depending on the mycotoxin to be tested. Only if the product performs well, with an efficiency above 80%, can it enter the next stage.
In vivo experiments
The second stage is in vivo experiments. Depending on the mycotoxin being tested, the same mycotoxin must be tested at the same time at levels between 1,000 ppb and 2,500 ppb, and tested on one specific animal species.
Target organs
In this experiment, the key part is that the anti-mycotoxin additive must statistically show a very effective and obvious effect on the target organ. For example, aflatoxin targets the liver, Fusarium moniliforme toxin targets the lungs, F2 toxin targets the reproductive organs, T2 toxin targets the oral organs, and so on. Therefore, the approved product is not only based on improving the immune system affected by mycotoxins or restoring the action of an enzyme, but must also prove that the product has a direct and effective effect on the target organ. In addition, in the aflatoxin and Fusarium moniliforme toxin tests, the mycotoxin adsorbent must statistically show obvious effects on body weight and feed intake, proving beyond doubt that the product works.
The third stage includes retesting the in vitro effect of the mycotoxin adsorbent every 6 months and the in vivo effect every 2 years, in order to ensure that manufacturers sell the same product as originally approved.
Very few products pass approval
This program was carried out one year ago and only very few products passed approval. The vast majority of products that passed are clay-based products:
Only 30% pass in vitro and in vivo testing and are proven usable in Brazil
• Currently only 30 products have passed, of which 29 are clay-based products-------------------the world's mainstream products are clay-based
• Since the implementation of the new regulations in 2007, no yeast-based adsorbent products have passed Brazilian testing.
Products that passed testing (30):
• Poultry: aflatoxin, 18; Fusarium, 2.
• Pigs: aflatoxin, 3; Fusarium, 1; F2, 6.
Cases where Myco-Ad passed:
• Poultry: aflatoxin, Fusarium (Myco-Ad AD)
• Pigs: aflatoxin, Fusarium, F2 (Myco-Ad AZ)
In pigs, there is only 1 product that is simultaneously effective against the 3 most important mycotoxins, and that is Myco-Ad AZ produced by the American company Special Nutrients.
The myth is shattered
Through the implementation of this approval program, together with confirmation of conclusions presented at other recent conferences including the U.S. Poultry Science and Animal Science meetings and the 2006 World Mycotoxin Forum, two myths have been shattered. (There have always been people attacking clay products)
1) Clay only works on aflatoxin;
2) All clays are equal
LAMIC has proven that some clays are very effective against several mycotoxins, including F2 toxin and Fusarium moniliforme toxin (such as Myco-Ad AZ). Brazilian producers should be proud of LAMIC's professional work, and should also thank the government's action for preventing the sale of mycotoxin adsorbents aimed at marketing rather than rigorous scientific evaluation.
For governments in other parts of the world that have not yet adopted a scientific method to approve mycotoxin adsorbent manufacturers, if the product provided has already been tested and approved by LAMIC, using such a product can protect oneself in the market.
Original text from:
Dr. Alberto Gimeno, technical consultant in animal nutrition and food/feed mycotoxicology
--------------------------------------
Dig. Sofa
--------------------------------------
This is a model of how things should be done
--------------------------------------
It's a bit messy, can't you format it properly?
What was originally clear has been made confusing.
A model country that effectively solves the mycotoxin problem
Brazil: has taken strong action on the mycotoxin problem
Brazil has set another example with its world-leading position. Twenty-five years ago they decided to stop relying only on oil, and then began producing ethanol from sugarcane, which is about 5 times more efficient than extracting it from corn, and it does not affect global feed or food prices. This time its leadership is shown in the mycotoxin issue.
Brazil is one of the world's largest grain producers and exporters of poultry meat and pork. For many years grain growers were very fortunate, because their only mycotoxin problem was aflatoxin. Over the past 4 years, this situation has changed dramatically. Fusarium moniliforme toxin, F2 toxin and deoxynivalenol began to be detected in corn, wheat and soybeans, and at very high levels, affecting animal production.
Mycotoxin adsorbents that claim to provide solutions to all problems appeared, and their greater purpose was to sell products rather than truly solve the problem. Faced with the mycotoxin problem and so many products, the Brazilian government decided to take tough measures to provide a true solution to this major problem.
Unlike the United States, where carcinogenic substances are not allowed to be added to feed, or the European Union, which has regulations stipulating very low doses of mycotoxins in feed, Brazilians solved this problem in a very effective and feasible way. They realized they had a mycotoxin problem, so they established a committee composed of scientists and experts in the mycotoxin field to create and develop methods and regulations for approving mycotoxin additives (adsorbents, detoxifiers).
The committee concluded that a program should be implemented, approving mycotoxin adsorbents through three stages of testing, conducted at Brazilian universities considered to be in a leading position in the mycotoxin field. The Federal University and the LAMIC laboratory were appointed to carry out this program.
The LAMIC laboratory was founded 15 years ago and is currently one of the world's top five leading independent mycotoxin laboratories. This laboratory has 9 sets of HPLC equipment and one MS/MS spectrophotometer dedicated solely to independent mycotoxin analysis. At the same time, they also have their own pig and poultry research center for in vivo animal experiments. LAMIC is a financially self-sufficient laboratory, and its main function is to provide services to farmers, not to mycotoxin adsorbent manufacturers.
In vitro experiments
The approval procedure begins with in vitro experiments, carried out with different levels of mycotoxin adsorbents at different pH values, with mycotoxin levels varying between 1,000 ppb and 2,500 ppb depending on the mycotoxin to be tested. Only if the product performs well, with an efficiency above 80%, can it enter the next stage.
In vivo experiments
The second stage is in vivo experiments. Depending on the mycotoxin being tested, the same mycotoxin must be tested at the same time at levels between 1,000 ppb and 2,500 ppb, and tested on one specific animal species.
Target organs
In this experiment, the key part is that the anti-mycotoxin additive must statistically show a very effective and obvious effect on the target organ. For example, aflatoxin targets the liver, Fusarium moniliforme toxin targets the lungs, F2 toxin targets the reproductive organs, T2 toxin targets the oral organs, and so on. Therefore, the approved product is not only based on improving the immune system affected by mycotoxins or restoring the action of an enzyme, but must also prove that the product has a direct and effective effect on the target organ. In addition, in the aflatoxin and Fusarium moniliforme toxin tests, the mycotoxin adsorbent must statistically show obvious effects on body weight and feed intake, proving beyond doubt that the product works.
The third stage includes retesting the in vitro effect of the mycotoxin adsorbent every 6 months and the in vivo effect every 2 years, in order to ensure that manufacturers sell the same product as originally approved.
Very few products pass approval
This program was carried out one year ago and only very few products passed approval. The vast majority of products that passed are clay-based products:
Only 30% pass in vitro and in vivo testing and are proven usable in Brazil
• Currently only 30 products have passed, of which 29 are clay-based products-------------------the world's mainstream products are clay-based
• Since the implementation of the new regulations in 2007, no yeast-based adsorbent products have passed Brazilian testing.
Products that passed testing (30):
• Poultry: aflatoxin, 18; Fusarium, 2.
• Pigs: aflatoxin, 3; Fusarium, 1; F2, 6.
Cases where Myco-Ad passed:
• Poultry: aflatoxin, Fusarium (Myco-Ad AD)
• Pigs: aflatoxin, Fusarium, F2 (Myco-Ad AZ)
In pigs, there is only 1 product that is simultaneously effective against the 3 most important mycotoxins, and that is Myco-Ad AZ produced by the American company Special Nutrients.
The myth is shattered
Through the implementation of this approval program, together with confirmation of conclusions presented at other recent conferences including the U.S. Poultry Science and Animal Science meetings and the 2006 World Mycotoxin Forum, two myths have been shattered. (There have always been people attacking clay products)
1) Clay only works on aflatoxin;
2) All clays are equal
LAMIC has proven that some clays are very effective against several mycotoxins, including F2 toxin and Fusarium moniliforme toxin (such as Myco-Ad AZ). Brazilian producers should be proud of LAMIC's professional work, and should also thank the government's action for preventing the sale of mycotoxin adsorbents aimed at marketing rather than rigorous scientific evaluation.
For governments in other parts of the world that have not yet adopted a scientific method to approve mycotoxin adsorbent manufacturers, if the product provided has already been tested and approved by LAMIC, using such a product can protect oneself in the market.
Original text from:
Dr. Alberto Gimeno, technical consultant in animal nutrition and food/feed mycotoxicology
--------------------------------------
Dig. Sofa
--------------------------------------
This is a model of how things should be done
--------------------------------------
It's a bit messy, can't you format it properly?
What was originally clear has been made confusing.