Nine questions and nine answers on feed antimicrobial peptides, understanding the key issues in one article
Nine questions on feed antimicrobial peptides
This post was last edited by Wang Sanong on 2009-11-27 17:54' V% R& H7 D3 U: A% S
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Feed antimicrobial peptides are very popular now. The South is holding a special seminar, and a big boss in the Central Plains has invested over 200 million to develop them. I do not know whether antimicrobial peptides belong to microecological products. I have some questions and would like to ask all you experts:- O2 t0 S* }j& s; V
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1. Feed antimicrobial peptides have not yet been officially approved. What exactly is still missing? --Safety/function/?
8 ~! Y% U& S8 S' W* l2. Has anyone actually done experiments on the practical effects of antimicrobial peptides as feed products?! C' q, B9 V8 I4 J$ |
3. Over the past thirty years, 1,500 kinds of natural antimicrobial peptides have been discovered internationally, but currently only about 5 are used clinically. What is the bottleneck? --Technology/market/access?: j2 Q$ U9 ^/ G[+ F
4. Is it true that: antimicrobial peptides should first be developed as drugs, with large early investment laying the groundwork for much pharmacological and toxicological research, as a necessary prerequisite for application development;6 m% L+ z" _5 y9 e
5. At present, how feasible are antimicrobial peptides for feed use? Who are the powerful opponents? What are they mainly opposing?4 d% c! A( U( c' I; s( h7 g* I7 |
6. Which domestic institutions and experts have technical advantages in antimicrobial peptides? Now that business and academia are combined, it is very hard for us grassroots people to ask/hear a single word of truth?$ {+ k$ K5 S1 Q1 x
7. There is a lot of media publicity material, so why are there no products on the market? Not even samples can be found
0 O/ o$ l: ?7 W, l3 U# p. [1 y* F8. What are the greatest advantages and greatest disadvantages of antimicrobial peptides (in terms of properties/functions, production/commercialization)?
2 d% o" A0 ?1 `' w, @" x9 Ya9. Foreign feed products now all enter the Chinese market very conveniently. Why is there not a single international company selling feed antimicrobial peptides in the Chinese market? Is the trend not strong enough, or has it passed its peak? Entrepreneurs never reject new things!
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These questions are so sharp, and also very good. I do not understand them very well either, but you have voiced what is in our hearts!
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In depth. It really is something that needs to be understood clearly. As for the answers -- I am looking for them too
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Let me try a few questions. First, question 1: feed antimicrobial peptides have not yet been officially approved. What exactly is still missing? --Safety/function/?9 2 Q8 {& Z& b2 FY, ?$ r
At present, antimicrobial peptides have already been approved for use abroad; domestically, I am not very sure. In terms of safety and function, there is no problem with antimicrobial peptides. The key issue is still cost. At present, there is still a lack of mature technology for large-scale production. This may be a bottleneck restricting the development of antimicrobial peptides.
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This post was last edited by horsegreenhill on 2009-11-29 00:160 m$ ^! i% W7 ~. o4 N) ~
8 E. S5 b5 q2 R; o" RQuestion 4: pharmacological and toxicological tests must be carried out. At present, the laboratory is engaged in related research.
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This post was last edited by horsegreenhill on 2009-11-29 00:208 WC6 G8 D; [# , : ~
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Let me answer these questions first. The other questions still need more thought.
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This post was last edited by Wang Sanong on 2009-11-29 09:38+ w/ f$ b: S0 J; Y2 O, j' R
L+ E; P; L2 Z+ m4 p8 WReply to 4#horsegreenhill
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1. Which country has approved their use abroad?
$ ?! j( z" ?) |2 c2. Abroad, are they used as feed additives or for therapeutic purposes?
& F+ M$ P/ ~4 C0 p( N3. If so, what variety (name) is it?3 ?6 M0 j% e6 I; j3 t: B& i$ Z
The fact is: antimicrobial peptides for human drug (food) use have long existed both domestically and abroad!
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Reply to 7#Wang Sanong
; Z: Q' 7 [ & u; V+ B0 l; R# BAs far as I know, the United Kingdom and the United States now use this type of product. Abroad, they are generally also used in food preservatives. The specific product name is nisin, which can be viewed through a Google search. I feel that the reason antimicrobial peptide products have not been used in the livestock industry is mainly the cost issue. Natural products have low yields and are difficult to separate and purify. Technology for genetically engineered bacteria is still under research, so the current situation has arisen. Comrade Wang, let us communicate more! If there is anything wrong, please help point it out! By the way, are you also in Beijing?
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Reply to 8#horsegreenhill a3 n$ S% T0 L1 S
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The so-called Nisin has already been approved for use as a food additive in China for many years
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Reply to 9#Wang Sanong
$ w$ d, ?2 ^( J+ A1 c+ gThe key to the current problem is why it has not been widely used in the livestock industry. Personally, I think it is still a matter of yield and cost.
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The problem seems not to be just that simple' N0 z0 t. G4 s/ g0
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Wang Sanong added the following content on 2009-11-29 16:01
( f( }/ {+ _, t3 z$ y; e4 o2 D+ L* L' D8 l8 |
The problem seems not to be just that simple
& F% b9 W0 P0 S) U+ h7 w
Feed antimicrobial peptides are very popular now. The South is holding a special seminar, and a big boss in the Central Plains has invested over 200 million to develop them. I do not know whether antimicrobial peptides belong to microecological products. I have some questions and would like to ask all you experts:- O2 t0 S* }j& s; V
" s0 @4 l' U0 i& `' l
1. Feed antimicrobial peptides have not yet been officially approved. What exactly is still missing? --Safety/function/?
8 ~! Y% U& S8 S' W* l2. Has anyone actually done experiments on the practical effects of antimicrobial peptides as feed products?! C' q, B9 V8 I4 J$ |
3. Over the past thirty years, 1,500 kinds of natural antimicrobial peptides have been discovered internationally, but currently only about 5 are used clinically. What is the bottleneck? --Technology/market/access?: j2 Q$ U9 ^/ G[+ F
4. Is it true that: antimicrobial peptides should first be developed as drugs, with large early investment laying the groundwork for much pharmacological and toxicological research, as a necessary prerequisite for application development;6 m% L+ z" _5 y9 e
5. At present, how feasible are antimicrobial peptides for feed use? Who are the powerful opponents? What are they mainly opposing?4 d% c! A( U( c' I; s( h7 g* I7 |
6. Which domestic institutions and experts have technical advantages in antimicrobial peptides? Now that business and academia are combined, it is very hard for us grassroots people to ask/hear a single word of truth?$ {+ k$ K5 S1 Q1 x
7. There is a lot of media publicity material, so why are there no products on the market? Not even samples can be found
0 O/ o$ l: ?7 W, l3 U# p. [1 y* F8. What are the greatest advantages and greatest disadvantages of antimicrobial peptides (in terms of properties/functions, production/commercialization)?
2 d% o" A0 ?1 `' w, @" x9 Ya9. Foreign feed products now all enter the Chinese market very conveniently. Why is there not a single international company selling feed antimicrobial peptides in the Chinese market? Is the trend not strong enough, or has it passed its peak? Entrepreneurs never reject new things!
--------------------------------------
These questions are so sharp, and also very good. I do not understand them very well either, but you have voiced what is in our hearts!
--------------------------------------
In depth. It really is something that needs to be understood clearly. As for the answers -- I am looking for them too
--------------------------------------
Let me try a few questions. First, question 1: feed antimicrobial peptides have not yet been officially approved. What exactly is still missing? --Safety/function/?9 2 Q8 {& Z& b2 FY, ?$ r
At present, antimicrobial peptides have already been approved for use abroad; domestically, I am not very sure. In terms of safety and function, there is no problem with antimicrobial peptides. The key issue is still cost. At present, there is still a lack of mature technology for large-scale production. This may be a bottleneck restricting the development of antimicrobial peptides.
--------------------------------------
This post was last edited by horsegreenhill on 2009-11-29 00:160 m$ ^! i% W7 ~. o4 N) ~
8 E. S5 b5 q2 R; o" RQuestion 4: pharmacological and toxicological tests must be carried out. At present, the laboratory is engaged in related research.
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This post was last edited by horsegreenhill on 2009-11-29 00:208 WC6 G8 D; [# , : ~
/ f4 ]& ~, D9 H+ Y1 v6 @: w" @
Let me answer these questions first. The other questions still need more thought.
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This post was last edited by Wang Sanong on 2009-11-29 09:38+ w/ f$ b: S0 J; Y2 O, j' R
L+ E; P; L2 Z+ m4 p8 WReply to 4#horsegreenhill
' k0 B# @& w/ W- t: v) H- e1 R$ G+ P* q& i+ R( U: c+ H: F2 l
1. Which country has approved their use abroad?
$ ?! j( z" ?) |2 c2. Abroad, are they used as feed additives or for therapeutic purposes?
& F+ M$ P/ ~4 C0 p( N3. If so, what variety (name) is it?3 ?6 M0 j% e6 I; j3 t: B& i$ Z
The fact is: antimicrobial peptides for human drug (food) use have long existed both domestically and abroad!
--------------------------------------
Reply to 7#Wang Sanong
; Z: Q' 7 [ & u; V+ B0 l; R# BAs far as I know, the United Kingdom and the United States now use this type of product. Abroad, they are generally also used in food preservatives. The specific product name is nisin, which can be viewed through a Google search. I feel that the reason antimicrobial peptide products have not been used in the livestock industry is mainly the cost issue. Natural products have low yields and are difficult to separate and purify. Technology for genetically engineered bacteria is still under research, so the current situation has arisen. Comrade Wang, let us communicate more! If there is anything wrong, please help point it out! By the way, are you also in Beijing?
--------------------------------------
Reply to 8#horsegreenhill a3 n$ S% T0 L1 S
) K7 J" p& g7 N# I% `0 i! H2 s
The so-called Nisin has already been approved for use as a food additive in China for many years
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Reply to 9#Wang Sanong
$ w$ d, ?2 ^( J+ A1 c+ gThe key to the current problem is why it has not been widely used in the livestock industry. Personally, I think it is still a matter of yield and cost.
--------------------------------------
The problem seems not to be just that simple' N0 z0 t. G4 s/ g0
' P, _. F! ?6 w5 M
Wang Sanong added the following content on 2009-11-29 16:01
( f( }/ {+ _, t3 z$ y; e4 o2 D+ L* L' D8 l8 |
The problem seems not to be just that simple